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吴瑞教授
作者:USMedEdu
发表时间:2008-02-23
更新时间:2008-02-23
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国际著名生物学家、美国康奈尔大学教授、中国工程院外籍院士吴瑞先生,因心脏遽停 (cardiac arrest),于2008年2月11日在美国去世,享年七十九岁。




  吴瑞教授在生命科学领域做出了举世公认的成就,对DNA生物化学及分子生物学的数个领域做出过重大贡献。他在国际上第一个建立了DNA核苷酸顺序的测定方法(1971年),他的策略是利用能定位的引物加以延伸合成新的有标记的DNA,这个基本策略改进后成为桑格的DNA快速测序法和穆利斯的DNA扩增的聚合酶链式反应(PCR)技术的基础。吴瑞教授和同事们首创了以合成的寡核苷酸衔接头和衔接子来提高平末端DNA克隆效率的方法,该法现已成为生物工程中的一种常规方法。他领导的研究组在水稻生物技术领域也取得了突破性成果,已初步成功培育出具有抗虫、耐旱、耐盐、耐寒特性的转基因超级水稻。

  吴瑞教授对中国科学事业的促进和发展也起了重要做用,他不仅多次回国讲学,而且为海峡两岸发展生物科学献计献策,是中国生物工程发展的首倡者之一。吴瑞教授在1981年初说服美国100多所一流大学接受来自中国大陆的留学生,最终促成CUSBEA(中美生物化学联合招生)项目成行。该项目于1981年首次招生,1982年首次派遣,迄今整整25年。到1989年最后一次派遣为止,8年时间里共派出425人,如今的这些“学子”们都已经成长为当今世界生命科学领域的顶尖专家,近200位CUSBEA学子在美国的大学担任助理教授以上的职位,其中包括王晓东、袁钧英、韩珉等知名学者。

  2007年7月24日,在清华大学召开的第五届华人生物学家协会年会及2007年生命科学前沿学术研讨会上,华人生物学家协会(CBIS,点击查看)授予吴瑞教授“终身成就奖”,表彰他对中国生命科学发展作出的历史性贡献。会议期间,吴瑞教授专门通过丁香园网站向广大生物医药领域的年轻研究生们致以诚挚的勉励。(点击查看)

  2008年2月11日,吴瑞教授因病在美国去世,享年七十九岁。

相关阅读:

丁香园七周年,Leroy Hood院士与吴瑞院士共同寄语丁香园全体会员!

美国生物界的华裔牛人们!

霍华得休斯医学研究所(HHMI) 的华裔研究员!



以下是丁香园在第一时间率先在国内网络媒体上所作的综合报道

惊闻吴瑞先生去世, 去年7月还与他老人家在北京会议上见面交谈,他还为我们论坛作了题词. 给我们许多谆谆教诲, 这么快就走了?

深切悼念这位为中国生命科学发展和人才培养作出的卓越贡献的学者

以下是施一公教授发来的讣告

Dear colleagues,

It is with profound sadness and sorrow that I announce the untimely death of Dr. Ray Wu, an accomplished scientist and a passionate advocate for biological research in China. Dr. Ray Wu passed away on Sunday, February 10th, at the age of 79. His death is a tremendous loss to the life science community.

Dr. Ray Wu left behind a rich scientific legacy. Among many major accomplishments, Dr. Wu was a pioneer in DNA sequencing and developed the first method for determining nucleotide sequences of DNA in 1970. His method resulted in determination of the complete sequence of the two cohesive ends of lambda phage DNA in 1971. His method was later adopted by Sanger in the development of an efficient strategy for sequencing DNA. Dr. Wu later shifted his research focus to transgenic rice production because he realized during his visits to China in the 1980s that food shortage would become a major problem in China.

For the last 27 years, Dr. Ray Wu played an important role in promoting biological research in China. He is best known for instigating the CUSBEA (China-United States Biochemistry and Molecular Biology Examination and Administration) Program, which brought a total of 425 Chinese students from mainland China to the United States for graduate education between 1982 and 1989. Many of these students have gone on to become leaders in their respective research areas. The CUSBEA Program and its stunning success have had a lasting impact on the research community in the United States and in China.

The Chinese Biological Investigators Society will sponsor a memorial symposium in memory of Dr. Ray Wu. Details of the symposium will be announced at a later time.

Sincerely,
Yigong Shi
On behalf of the Board of Directors
Chinese Biological Investigators Society
(http://www.CBISociety.org/)

A native of Beijing and a naturalized citizen of the United States, Wu earned his B.S. in chemistry in 1950 at University of Alabama and his Ph.D. in biochemistry in 1955 at the University of Pennsylvania. Before joining Cornell's Section of Biochemistry and Molecular Biology in 1966, Wu was a biochemist in the Public Health Research Institute of the city of New York.

He also has taught or conducted research at Stanford University, the MRC Laboratory in Cambridge, England, and Massachusetts Institute of Technology. He serves as an adjunct professor at Beijing University and is an honorary research scientist at 10 other institutes in China.

“The current focus of research in my laboratory is on regenerating transgenic rice plants transformed with agronomically useful genes. We have succeeded in transforming intact rice cells using high-velocity microprojectiles, as well as the Agrobacterium-based method, which has resulted in the regeneration of many fertile transgenic rice plants. Genes coding for the following proteins have been used to transform rice cells: protease inhibitors for producing insect-resistant plants, LEA3, LEA2, pyrroline-5 carboxylate synthetase, arginine carboxylase, and trehalose-6-P synthase and phosphatase for producing transgenic plants that are tolerant to drought, high levels of salt and low temperature. Other agronomically useful genes will be added to the list in the future…”

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